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Combined measure of salivary alpha-synuclein species as diagnostic biomarker for Parkinson’s disease

8 Aug 2023

Abstract excerpt

Parkinson's disease (PD) diagnosis is still vulnerable to bias, and a definitive diagnosis often relies on post-mortem neuropathological diagnosis. In this regard, alpha-synuclein (αsyn)-specific in vivo biomarkers remain a critical unmet need, based on its relevance in the neuropathology. Specifically, content changes in αsyn species such as total (tot-αsyn), oligomeric (o-αsyn), and phosphorylated (p-αsyn)...

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PMID: 37552278
DOI: 10.1007/s00415-023-11893-x

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