Article

Cyclin A2 Induces Cytokinesis in Human Adult Cardiomyocyte and Drives Reprogramming in Mice

2024-03-02

Abstract excerpt

Cyclin A2 (CCNA2), a master cell cycle regulator silenced in postnatal cardiomyocytes, promotes cardiac repair in animal models. However, its effect on cytokinesis in adult human cardiomyocytes remains unknown. We engineered a replication-deficient adenoviral vector encoding human CCNA2 under the cardiac Troponin T promoter and delivered it to freshly isolated cardiomyocytes from adult human hearts. Time-lapse liv...

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Literature Corpus work: 0098cdc0-7da1-566b-94e7-d944501391c4
DOI: 10.1101/2024.03.01.583057

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