Article

Transient Cell Cycle Induction in Cardiomyocytes to Treat Ischemic Heart Failure

2020-12-28

Abstract excerpt

<title>Abstract</title> <p>The regenerative capacity of the heart after myocardial infarction (MI) is limited. Our previous study showed that ectopic introduction of Cdk1/CyclinB1 and Cdk4/CyclinD1 complexes (4F) promotes cardiomyocyte proliferation in 15-20% of infected cardiomyocytes <italic>in vitro</italic> and <italic>in vivo </italic>and improves cardiac function after MI. Here, we aim to<bold> </bold>ident...

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Literature Corpus work: 7ba21d62-d024-583c-b2b6-a814ba9f199d
DOI: 10.21203/rs.3.rs-122026/v1

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