Article

Cyclin A2 Induces Human Adult Cardiomyocyte Cytokinesis and Elicits Cardiomyocyte Reprogramming and Dedifferentiation

2025-05-15

Abstract excerpt

<title>Abstract</title> <p>Cyclin A2 (CCNA2), a master cell cycle regulator, is silenced in postnatal mammalian cardiomyocytes. We have previously demonstrated its ability to promote cardiac repair in small and large animals when delivered to the heart via a viral vector. However, the effect of CCNA2 gene delivery on cytokinesis in isolated cardiomyocytes from adult human hearts has not been explored. We designed...

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Literature Corpus work: 9cdc8a68-9d15-5a2f-ba88-79cffd5145ff
DOI: 10.21203/rs.3.rs-6597490/v1

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