Development of adeno-associated viral vectors targeting cardiac fibroblasts for efficient in vivo cardiac reprogramming

Abstract excerpt

Overexpression of cardiac reprogramming factors, including GATA4, HAND2, TBX5, and MEF2C (GHT/M), can directly reprogram cardiac fibroblasts (CFs) into induced cardiomyocytes (iCMs). Adeno-associated virus (AAV) vectors are widely used clinically, and vectors targeting cardiomyocytes (CMs) have been extensively studied. However, safe and efficient AAV vectors targeting CFs for in vivo cardiac reprogramming remain...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiac Fibrosis and Remodeling
• Share to Viral Infections and Immunology Research
• Share to Virus-based gene therapy research