Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface

Abstract excerpt

Whooping cough, or pertussis, is a contagious disease of the respiratory tract that is reemerging worldwide despite high vaccination coverage.The causative agent of this disease is the Gram-negative Bordetella pertussis.Knowledge on complement evasion strategies of this pathogen is limited.However, this is of great importance for future vaccine development as it has become apparent that a novel pertussis vaccine...

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