Article

A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota

2023-10-09

Abstract excerpt

Insertion sequence (IS) elements are mobile genetic elements in bacterial genomes that support adaptation. We developed a database of IS elements coupled to a computational pipeline that identifies IS element insertions in the microbiota. We discovered that diverse IS elements insert into the genomes of intestinal bacteria regardless of human host lifestyle. These insertions target bacterial accessory genes that a...

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Literature Corpus work: faf5f612-9a53-5cc0-b815-587e963b0945
DOI: 10.1101/2023.10.06.561241

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