Article

High-resolution lineage tracking of within-host evolution and strain transmission in a human gut symbiont across ecological scales

2024-02-20

Abstract excerpt

<h4>Summary</h4> Gut bacteria rapidly evolve in vivo , but their long-term success requires dispersal across hosts. Here, we quantify this interplay by tracking >50,000 genomically barcoded lineages of the prevalent commensal Bacteroides thetaiotaomicron ( Bt ) among co-housed mice. We find that adaptive mutations rapidly spread between hosts, overcoming the natural colonization resistance of resident Bt stra...

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Literature Corpus work: e06f74ea-f7b1-585d-bd4d-41572742f54c
DOI: 10.1101/2024.02.17.580834

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