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Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization

1 Aug 2023

Abstract excerpt

To understand how a bacterium ultimately succeeds or fails in adapting to a new host, it is essential to assess the temporal dynamics of its fitness over the course of colonization. Here, we introduce a human-derived commensal organism, Bacteroides thetaiotaomicron (Bt), into the guts of germ-free mice to determine whether and how the genetic requirements for colonization shift over time. Combining a...

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PMID: 37598339
DOI: 10.1016/j.celrep.2023.113009

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