Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cleavage of FNDC5 and insights into its maturation process.

Molecular and cellular endocrinology - 15 Jun 2020

Nie Yongwei, Dai Bai, Guo Xudong, Liu Dongjun

Abstract excerpt

FNDC5 corresponds to an irisin precursor that increases with exercise. Studies suggest that irisin mediates beneficial effects in adipose tissues, skeletal muscle, bone, and brain. However, the cleavage and maturation processes of FNDC5 have not been clearly identified. This study aimed to show that the signal peptide and transmembrane domain of FNDC5 were associated with the secretion of its ectodomain....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HeLa Cells
Share to Amino Acid Sequence
Share to Fibronectins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

Share to HEK293 Cells

Share to Models, Biological

Share to Mutation

Share to Protein Domains

Source

Identifiers

PMID: 32360564
DOI: 10.1016/j.mce.2020.110840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cleavage of FNDC5 and insights into its maturation process.PMID 32360564Read ↗

Progress and Challenges in the Biology of FNDC5 and IrisinSemantic proximity Read ↗

Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and miceSemantic proximity Read ↗

Irisin in Reproduction: Its Roles and Therapeutic Potential in Male and Female Fertility DisordersSemantic proximity Read ↗

Endotrophin, a Key Marker and Driver for Fibroinflammatory DiseaseSemantic proximity Read ↗

Glucocorticoid receptor positively regulates transcription of FNDC5 in the liverSemantic proximity Read ↗

Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative DiseasesSemantic proximity Read ↗

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin ResistanceSemantic proximity Read ↗

GDF11 and aging biology - controversies resolved and pendingSemantic proximity Read ↗

Exercise hormone irisin is a critical regulator of cognitive function.Semantic proximity Read ↗

Loss of DDRGK1 Impairs IRE1α UFMylation to Promote IRE1α Degradation, ER Stress and Apoptosis in ATDC5 CellsSemantic proximity Read ↗

Expression of Irisin/FNDC5 in Breast CancerSemantic proximity Read ↗

Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.