Article

Dual Control of LDL-cholesterol Levels by ANGPTL3 and ANGPTL8

2026-04-01

Abstract excerpt

<h4>BACKGROUND</h4> Inactivation of ANGPTL3 (angiopoietin-like protein 3, A3) is a proven therapeutic strategy for lowering plasma lipid levels independently of the LDL receptor (LDLR), yet the optimal approach to inactivate A3 remains unclear. A3 is proteolytically cleaved and circulates as full-length (A3-FL), N-terminal (A3-Nter) and C-terminal (A3-Cter) fragments. The specific contribution of each form of A3,...

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Literature Corpus work: 12a709dd-541e-5476-96a3-cdc2c633da68
DOI: 10.64898/2026.03.30.715445

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