Article

Bimodal sequence composition underlies functional duality of transcribed enhancers

2020-08-20

Abstract excerpt

<h4>Background: </h4> Recent studies have drawn attention to transcribed enhancers (trEs) as important regulatory elements of gene expression; however, their characteristics and mechanisms of action remain poorly understood. <h4>Results:</h4> We profiled the characteristics of trEs and obtained insights into their mechanisms of action. We found that trEs harbor functional duality related to bimodal sequence compos...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0028689d-5106-5495-af10-d91ad411e1fe
DOI: 10.21203/rs.3.rs-55967/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bimodal sequence composition underlies functional duality of transcribed enhancersDOI 10.21203/rs.3.rs-55967/v1Read

Motif signatures of transcribed enhancersSemantic proximity Read

A hypothetical model of trans-acting R-loops-mediated promoter-enhancer interactions by Alu elements.Semantic proximity Read

Genomic codes governing enhancer RNA fateSemantic proximity Read

Comprehensive Evaluation of Diverse Massively Parallel Reporter Assays to Functionally Characterize Human Enhancers Genome-wideSemantic proximity Read

Profiling of transcribed <i>cis</i> -regulatory elements in single cellsSemantic proximity Read

Modeling the Evolutionary Architectures of Transcribed Human Enhancer Sequences Reveals Distinct Origins, Functions, and Associations with Human Trait Variation.Semantic proximity Read

Compatibility logic of human enhancer and promoter sequencesSemantic proximity Read

Short DNA sequence patterns accurately identify broadly active human enhancersSemantic proximity Read

Sequence determinants of human gene regulatory elementsSemantic proximity Read

A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer.Semantic proximity Read

Massively parallel characterization of transcriptional regulatory elements in three diverse human cell typesSemantic proximity Read

eRNA-IDO: a one-stop platform for identification, interactome discovery and functional annotation of enhancer RNAsSemantic proximity Read