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Article

A hypothetical model of trans-acting R-loops-mediated promoter-enhancer interactions by Alu elements.

Journal of genetics and genomics = Yi chuan xue bao - 20 Nov 2021

Bai Xue, Li Feifei, Zhang Zhihua

Abstract excerpt

Enhancers modulate gene expression by interacting with promoters. Models of enhancer-promoter interactions (EPIs) in the literature involve the activity of many components, including transcription factors and nucleic acid. However, the role that sequence similarity plays in EPIs remains largely unexplored. Herein, we report that Alu-derived sequences dominate sequence similarity between enhancers and promoters....

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Identifiers

PMID: 34531149
DOI: 10.1016/j.jgg.2021.07.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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