Article

Targeting OLIG2 increases therapeutic responses in SHH medulloblastoma mouse models and patient-derived medulloblastoma organoids

2022-02-16

Abstract excerpt

<h4>SUMMARY</h4> Recurrence after therapy is the primary life-threatening complication of medulloblastoma. In Sonic Hedgehog (SHH)-subgroup medulloblastoma, OLIG2-expressing tumour stem cells are crucial to recurrence. We investigated the potential of the small-molecule OLIG2 inhibitor CT-179 to decrease recurrence in patient-derived organoids, mice genetically-engineered to develop SHH-driven MB, and mice with M...

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Identifiers and source

Literature Corpus work: 00125662-8df6-500a-ad1f-c442e0d60d42
DOI: 10.1101/2022.02.14.480293

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