Article
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis.
The Lancet. Oncology - 1 Nov 2013
Ramaswamy Vijay, Remke Marc, Bouffet Eric, Faria Claudia C, Perreault Sebastien, Cho Yoon-Jae, Shih David J, Luu Betty, Dubuc Adrian M, Northcott Paul A, Schüller Ulrich, Gururangan Sridharan, McLendon Roger, Bigner Darell, Fouladi Maryam, Ligon Keith L, Pomeroy Scott L, Dunn Sandra, Triscott Joanna, Jabado Nada, Fontebasso Adam, Jones David T W, Kool Marcel, Karajannis Matthias A, Gardner Sharon L, Zagzag David, Nunes Sofia, Pimentel José, Mora Jaume, Lipp Eric, Walter Andrew W, Ryzhova Marina, Zheludkova Olga, Kumirova Ella, Alshami Jad, Croul Sidney E, Rutka James T, Hawkins Cynthia, Tabori Uri, Codispoti Kari-Elise T, Packer Roger J, Pfister Stefan M, Korshunov Andrey, Taylor Michael D
Abstract excerpt
BACKGROUND: Recurrent medulloblastoma is a therapeutic challenge because it is almost always fatal. Studies have confirmed that medulloblastoma consists of at least four distinct subgroups. We sought to delineate subgroup-specific differences in medulloblastoma recurrence patterns. METHODS: We retrospectively identified a discovery cohort of all recurrent medulloblastomas at the Hospital for Sick Children...
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