Article

CK1α agonists attenuate medulloblastoma stemness and relapse risk

2025-11-11

Abstract excerpt

<title>Abstract</title> <p> While outcomes for most children with medulloblastoma (MB) are relatively favorable, those in the Sonic Hedgehog (SHH) subgroup with <italic>Tumor Protein P53</italic> ( <italic>TP53</italic> ) mutations–known as the SHHα subtype–face a much poorer prognosis. SHHα patients relapse more frequently and rapidly, underscoring the need for therapies that prevent recurrence. We recently...

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Literature Corpus work: 09a52dcc-8714-5b4e-91d0-8c0b267e4e2f
DOI: 10.21203/rs.3.rs-7915551/v1

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