Article

Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using OLIG2 inhibitor CT-179

2023-06-09

Abstract excerpt

<title>Abstract</title> <p>Recurrence is the primary life-threatening complication for medulloblastoma (MB). In Sonic Hedgehog (SHH)-subgroup MB, OLIG2-expressing tumor stem cells drive recurrence. We investigated the anti-tumor potential of the small-molecule OLIG2 inhibitor CT-179, using SHH-MB patient-derived organoids, patient-derived xenograft (PDX) tumors and mice genetically-engineered to develop SHH-MB. C...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82df81a8-5ebc-513b-b254-3a9315fc6690
DOI: 10.21203/rs.3.rs-2949436/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Preventing recurrence in Sonic Hedgehog Subgroup Medulloblastoma using OLIG2 inhibitor CT-179DOI 10.21203/rs.3.rs-2949436/v1Read

Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179Semantic proximity Read

Targeting OLIG2 increases therapeutic responses in SHH medulloblastoma mouse models and patient-derived medulloblastoma organoidsSemantic proximity Read

CK1α agonists attenuate medulloblastoma stemness and relapse riskSemantic proximity Read

Medulloblastoma in the Molecular EraSemantic proximity Read

Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile.Semantic proximity Read

Therapeutic opportunities for medulloblastoma come of age.Semantic proximity Read

Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed MedulloblastomaSemantic proximity Read

Medulloblastoma in the age of molecular subgroups: a reviewSemantic proximity Read

Clinico-radiological outcomes in WNT-subgroup medulloblastomaSemantic proximity Read

Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profileSemantic proximity Read

Molecular markers and potential therapeutic targets in non-WNT/non-SHH (group 3 and group 4) medulloblastomasSemantic proximity Read

Spatial and temporal transcriptomics of SHH-medulloblastoma with chromothripsis identifies multiple genetic clones that resist to treatment and lead to relapseSemantic proximity Read