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Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD

18 Feb 2021

Abstract excerpt

) repeats that have been implicated to lead to three main modes of disease pathology: loss of function of the C9ORF72 protein, the generation of RNA foci, and the production of dipeptide repeat proteins (DPRs) through repeat-associated non-AUG (RAN) translation. Five different DPRs are currently known to be formed: glycine-alanine (GA) and glycine-arginine (GR) from the sense strand, proline-alanine (PA), and...

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PMID: 33679328
DOI: 10.3389/fncel.2021.637548

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