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The Fragile X Protein Family in Amyotrophic Lateral Sclerosis

29 Mar 2023

Abstract excerpt

The fragile X protein (FXP) family comprises the multifunctional RNA-binding proteins FMR1, FXR1, and FXR2 that play an important role in RNA metabolism and regulation of translation, but also in DNA damage and cellular stress responses, mitochondrial organization, and more. FMR1 is well known for its implication in neurodevelopmental diseases. Recent evidence suggests substantial contribution of this protein...

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PMID: 36991279
DOI: 10.1007/s12035-023-03330-x

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