Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.

The Journal of cell biology - 18 Apr 2011

Zhang Shichuan, Yajima Hirohiko, Huynh Hoangdinh, Zheng Junke, Callen Elsa, Chen Hua-Tang, Wong Nancy, Bunting Samuel, Lin Yu-Fen, Li Mengxia, Lee Kyung-Jone, Story Michael, Gapud Eric, Sleckman Barry P, Nussenzweig André, Zhang Cheng Cheng, Chen David J, Chen Benjamin P C

Abstract excerpt

The nonhomologous end-joining (NHEJ) pathway is essential for radioresistance and lymphocyte-specific V(D)J (variable [diversity] joining) recombination. Defects in NHEJ also impair hematopoietic stem cell (HSC) activity with age but do not affect the initial establishment of HSC reserves. In this paper, we report that, in contrast to deoxyribonucleic acid (DNA)-dependent protein kinase catalytic subunit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Linking Reagents
Share to DNA-Activated Protein Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to Fanconi Anemia

Share to Gene Knock-In Techniques

Share to Hematopoiesis

Share to Hematopoietic Stem Cells

Share to Hyperpigmentation

Source

Open in PubMed Open full text

Identifiers

PMID: 21482716
DOI: 10.1083/jcb.201009074
PMCID: PMC3080267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.PMID 21482716Read ↗

Restoration of T cell-specific V(D)J recombination in DNA-PKcs(-/-) mice by ionizing radiation: The effects on survival, development, and tumorigenesis.Semantic proximity Read ↗

Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.Semantic proximity Read ↗

A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination.Semantic proximity Read ↗

DNA-PKcs Suppresses Illegitimate Chromosome RearrangementsSemantic proximity Read ↗

DNA-PKcs suppresses illegitimate chromosome rearrangementsSemantic proximity Read ↗

The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency.Semantic proximity Read ↗

DNA-PKcs and ATM co-regulate DNA double-strand break repair.Semantic proximity Read ↗

DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break RepairSemantic proximity Read ↗

The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic CellsSemantic proximity Read ↗

Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs).Semantic proximity Read ↗

Epidermal growth factor receptor–dependent DNA repair promotes murine and human hematopoietic regenerationSemantic proximity Read ↗

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.