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Article

Murine Prkdc polymorphisms impact DNA-PKcs function.

Radiation research - 1 Apr 2011

Fabre Kristin M, Ramaiah Lila, Dregalla Ryan C, Desaintes Christian, Weil Michael M, Bailey Susan M, Ullrich Robert L

Abstract excerpt

Polymorphic variants of DNA repair genes can increase the carcinogenic potential of exposure to ionizing radiation. Two single nucleotide polymorphisms (SNPs) in Prkdc, the gene encoding the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), have been identified in BALB/c mice and linked to reduced DNA-PKcs activity and mammary cancer susceptibility. We examined three additional mouse strains to better...

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Identifiers

PMID: 21265624
DOI: 10.1667/RR2431.1
PMCID: PMC3102216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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