Article
Oxidative stress in Huntington's disease.
Brain pathology (Zurich, Switzerland) - 1 Jan 1999
Browne S E, Ferrante R J, Beal M F
Abstract excerpt
It has been five years since the elucidation of the genetic mutation underlying the pathogenesis of Huntington's disease (HD) (97), however the precise mechanism of the selective neuronal death it propagates still remains an enigma. Several different etiological processes may play roles, and strong evidence from studies in both humans and animal models suggests the involvement of energy metabolism dysfunction,...
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