Article
Protein oxidation in Huntington disease.
BioFactors (Oxford, England) - 1 Jan 2000
Sorolla M Alba, Rodríguez-Colman María José, Vall-llaura Núria, Tamarit Jordi, Ros Joaquim, Cabiscol Elisa
Abstract excerpt
Huntington disease (HD) is an inherited neurodegenerative disorder caused by expansion of CAG repeats in the huntingtin gene, affecting initially the striatum and progressively the cortex. Oxidative stress, and consequent protein oxidation, has been described as important to disease progression. This review focuses on recent advances in the field, with a particular emphasis on the identified target proteins and...
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