Article
Study of oxidative damage and antioxidant systems in two Huntington's disease rodent models.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Pérez-Severiano Francisca, Montes Sergio, Gerónimo-Olvera Cristian, Segovia José
Abstract excerpt
Huntington's disease (HD) is a hereditary neurodegenerative disorder, characterized by motor, psychiatric, and cognitive symptoms. The genetic defect responsible for the onset of the disease, expansion of CAG repeats in exon 1 of the gene that codes for huntingtin, has been unambiguously identified. The mechanisms by which the mutation causes the disease are not completely understood yet. However, defects in the...
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