Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.

The Journal of biological chemistry - 19 Feb 1999

Zhang Z, Elly C, Altman A, Liu Y C

Abstract excerpt

We previously showed that an oncogenic Cbl mutant (70Z) is constitutively active in transcriptional activation of nuclear factor at activated T cells (NFAT). However, the mechanism underlying this effect remains unclear. Here we analyzed the effects of 70Z mutations at an amino-terminal loss of function site (Gly-306) and at carboxyl-terminal potential tyrosine or serine phosphorylation sites on association with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Jurkat Cells
Share to NFATC Transcription Factors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phosphorylation

Share to Proteins

Share to Receptors, Antigen, T-Cell

Share to Retroviridae Proteins, Oncogenic

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 9988730
DOI: 10.1074/jbc.274.8.4883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.PMID 9988730Read ↗

The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Semantic proximity Read ↗

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.Semantic proximity Read ↗

Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.Semantic proximity Read ↗

Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity.Semantic proximity Read ↗

ZAP-70 in Signaling, Biology, and DiseaseSemantic proximity Read ↗

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.Semantic proximity Read ↗

The cbl oncogene: a novel substrate of protein tyrosine kinases.Semantic proximity Read ↗

Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.Semantic proximity Read ↗

The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase.Semantic proximity Read ↗

Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.Semantic proximity Read ↗

A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase.Semantic proximity Read ↗

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.