Article
The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.
Molecular and cellular biology - 1 Oct 1999
van Leeuwen J E, Paik P K, Samelson L E
Abstract excerpt
T-cell receptor (TCR) engagement results in the activation of Src family (Lck and Fyn) and ZAP-70 protein tyrosine kinases, leading to tyrosine phosphorylation of multiple cellular substrates including the complex adapter protein c-Cbl. Moreover, Cbl is tyrosine phosphorylated upon engagement of growth factor receptors, cytokine receptors, and immunoreceptors and functions as a negative regulator of tyrosine...
Topics
- Binding Sites
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Humans
- Jurkat Cells
- Models, Biological
- Mutation
- NFATC Transcription Factors
- Nuclear Proteins
- Phosphorylation
- Protein Binding
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins