Article
Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.
The Journal of biological chemistry - 11 Aug 1995
Wange R L, Guitián R, Isakov N, Watts J D, Aebersold R, Samelson L E
Abstract excerpt
ZAP-70 is an 70-kDa protein tyrosine kinase, expressed exclusively in T cells and NK cells, and plays a critical role in mediating T cell activation in response to T cell receptor engagement. The strong correlation between tyrosine phosphorylation of ZAP-70 and its acquisition of increased kinase activity suggests that is is positively regulated by tyrosine phosphorylation. Previously, we identified tyrosines 492...
Topics
- Amino Acid Sequence
- Cells, Cultured
- Enzyme Activation
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Structure-Activity Relationship
- Transfection
- Tyrosine
- ZAP-70 Protein-Tyrosine Kinase