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Article

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

The Journal of biological chemistry - 11 Aug 1995

Wange R L, Guitián R, Isakov N, Watts J D, Aebersold R, Samelson L E

Abstract excerpt

ZAP-70 is an 70-kDa protein tyrosine kinase, expressed exclusively in T cells and NK cells, and plays a critical role in mediating T cell activation in response to T cell receptor engagement. The strong correlation between tyrosine phosphorylation of ZAP-70 and its acquisition of increased kinase activity suggests that is is positively regulated by tyrosine phosphorylation. Previously, we identified tyrosines 492...

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Identifiers

PMID: 7642520
DOI: 10.1074/jbc.270.32.18730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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