Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

doi:10.1002/j.1460-2075.1994.tb06773.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

The EMBO journal - 3 Oct 1994

Andoniou C E, Thien C B, Langdon W Y

Abstract excerpt

v-cbl is the transforming gene of a murine retrovirus which induces pre-B cell lymphomas and myelogenous leukaemias. It encodes 40 kDa of a gag fusion protein which is localized in the cytoplasm and nucleus of infected cells. The c-cbl oncogene encodes a 120 kDa cytoplasmic protein and its overexpression is not associated with tumorigenesis. The c-cbl sequence has shown that v-cbl was generated by a truncation...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cell Transformation, Neoplastic
Cytoplasm
Fusion Proteins, bcr-abl
HeLa Cells
Humans
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oncogene Protein v-cbl

Oncogene Proteins v-abl

Phosphorylation

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-cbl

Source

Open in PubMed Open full text

Identifiers

PMID: 7925293
DOI: 10.1002/j.1460-2075.1994.tb06773.x
PMCID: PMC395384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7925293-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.PMID 7925293Read ↗

The cbl oncogene: a novel substrate of protein tyrosine kinases.Semantic proximity Read ↗

Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity.Semantic proximity Read ↗

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disordersSemantic proximity Read ↗

Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.Semantic proximity Read ↗

Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.Semantic proximity Read ↗

The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Semantic proximity Read ↗

Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.Semantic proximity Read ↗

E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.Semantic proximity Read ↗

The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases.Semantic proximity Read ↗

CBL mutations promote activation of PI3K/AKT signaling via LYN kinaseSemantic proximity Read ↗

A role of the protein Cbl in FGF-2-induced angiogenesis in murine brain endothelial cells.Semantic proximity Read ↗

Loss of function Cbl-c mutations in solid tumorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.