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Article

Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.

The Journal of experimental medicine - 1 Feb 1996

Qian D, Mollenauer M N, Weiss A

Abstract excerpt

Zeta-associated protein (ZAP)-70 is a cytoplasmic protein tyrosine required for T cell antigen receptor (TCR) signaling and development. Mutations in ZAP-70 result in severe combined immunodeficiency in humans. ZAP-70 interacts with the TCR by binding to tyrosine-phosphorylated immunoreceptor tyrosine-based activation motifs (ITAMs) present in the invariant subunits of the TCR complex. Here we report that two...

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Identifiers

PMID: 8627172
DOI: 10.1084/jem.183.2.611
PMCID: PMC2192449

Genes

GRB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.PMID 8627172Read ↗

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A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.Semantic proximity Read ↗

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