Article
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
The Journal of experimental medicine - 1 Feb 1996
Qian D, Mollenauer M N, Weiss A
Abstract excerpt
Zeta-associated protein (ZAP)-70 is a cytoplasmic protein tyrosine required for T cell antigen receptor (TCR) signaling and development. Mutations in ZAP-70 result in severe combined immunodeficiency in humans. ZAP-70 interacts with the TCR by binding to tyrosine-phosphorylated immunoreceptor tyr...
Topics
- Adaptor Proteins, Signal Transducing
- CD8 Antigens
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle Proteins
- GRB2 Adaptor Protein
- Genes, Reporter
- Humans
- Membrane Proteins
- Mitogen-Activated Protein Kinase 1
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases
- Proteins
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-vav
- Receptors, Antigen, T-Cell
- Recombinant Fusion Proteins
- Signal Transduction