Article
Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyrA and parC.
Antimicrobial agents and chemotherapy - 1 Dec 1998
Gibreel A, Sjögren E, Kaijser B, Wretlind B, Sköld O
Abstract excerpt
Quinolone resistance in clinical isolates of Campylobacter jejuni in Sweden increased more than 20-fold at the beginning of the 1990s. Resistance to 125 microgram of ciprofloxacin per ml in clinical isolates was associated with chromosomal mutations in C. jejuni leading to a Thr-86-Ile substituti...
Topics
- 4-Quinolones
- Amino Acid Sequence
- Amino Acid Substitution
- Anti-Infective Agents
- Base Sequence
- Campylobacter jejuni
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Genes, Bacterial
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sweden