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Article

Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyrA and parC.

Antimicrobial agents and chemotherapy - 1 Dec 1998

Gibreel A, Sjögren E, Kaijser B, Wretlind B, Sköld O

Abstract excerpt

Quinolone resistance in clinical isolates of Campylobacter jejuni in Sweden increased more than 20-fold at the beginning of the 1990s. Resistance to 125 microgram of ciprofloxacin per ml in clinical isolates was associated with chromosomal mutations in C. jejuni leading to a Thr-86-Ile substitution in the gyrA product and a Arg-139-Gln substitution in the parC product.

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Identifiers

PMID: 9835526
DOI: 10.1128/AAC.42.12.3276
PMCID: PMC106034

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