Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC.

Antimicrobial agents and chemotherapy - 1 Mar 2011

Briales A, Rodríguez-Martínez J M, Velasco C, Díaz de Alba P, Domínguez-Herrera J, Pachón J, Pascual A

Abstract excerpt

This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in GyrA, Ser80Arg substitution in ParC, and qnr gene expression increased the MIC of ciprofloxacin to 2 μg/ml. qnr genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ciprofloxacin
Share to DNA Gyrase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Topoisomerase IV

Share to Escherichia coli

Share to Escherichia coli Proteins

Share to Fluoroquinolones

Share to Microbial Sensitivity Tests

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 21173174
DOI: 10.1128/AAC.00927-10
PMCID: PMC3067081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC.PMID 21173174Read ↗

Phenotypic and genotypic quinolone resistance in Escherichia coli underlining GyrA83/87 mutations as a target to detect ciprofloxacin resistance.Semantic proximity Read ↗

Quantifying the contribution of four resistance mechanisms to ciprofloxacin minimum inhibitory concentration in <i>Escherichia coli</i> : a systematic reviewSemantic proximity Read ↗

Chromosomal mutations that accompany qnr in clinical isolates of Escherichia coli.Semantic proximity Read ↗

The role of Gene Mutations (gyrA, parC) in Resistance to Ciprofloxacin in Clinical Isolates of Pseudomonas AeruginosaSemantic proximity Read ↗

Observation of a New Pattern of Mutations in gyrA and parC within Escherichia coli Exhibiting Fluroquinolone ResistanceSemantic proximity Read ↗

QnrS1 structure-activity relationships.Semantic proximity Read ↗

The role of gyrA and parC mutations in fluoroquinolones-resistant Pseudomonas aeruginosa isolates from Iran.Semantic proximity Read ↗

Alterations in the gyrA and parC genes in Salmonella spp. following in vitro exposure to fluoroquinolones.Semantic proximity Read ↗

Fluoroquinolone resistance mechanisms in an Escherichia coli isolate, HUE1, without quinolone resistance-determining region mutationsSemantic proximity Read ↗

Mutations in the gyrA, parC, and mexR genes provide functional insights into the fluoroquinolone-resistant Pseudomonas aeruginosa isolated in VietnamSemantic proximity Read ↗

In vitro antibacterial activities of new fluoroquinolones against clinical isolates of haemophilus influenzae with ciprofloxacin-resistance-associated alterations in GyrA and ParC.Semantic proximity Read ↗

A novel parC mutation potentiating fluoroquinolone resistance in Klebsiella pneumoniae and Escherichia coli clinical isolates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.