Alterations in the gyrA and parC genes in Salmonella spp. following in vitro exposure to fluoroquinolones.

doi:10.1179/joc.2006.18.3.250

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Article

Alterations in the gyrA and parC genes in Salmonella spp. following in vitro exposure to fluoroquinolones.

Journal of chemotherapy (Florence, Italy) - 1 Jun 2006

Cebrian L, Escribano I, Rodriguez J C, Royo G

Abstract excerpt

We characterize alterations in the QRDR fragment of gyrA and parC in Salmonella spp. following repeated exposure to different quinolones in two in vitro models. Mutations in QRDR of gyrA were found in only 25% of the mutants. The most frequent mutations were Asp87(R)Asn and Asp87(R)Tyr. Strains with the former mutation had a higher ciprofloxacin MIC than those with the latter. We did not find mutations in parC....

Topics

Anti-Bacterial Agents
DNA Gyrase
DNA Topoisomerase IV
Dose-Response Relationship, Drug
Fluoroquinolones
Microbial Sensitivity Tests
Mutation
Salmonella

Source

Open in PubMed

Identifiers

PMID: 17129834
DOI: 10.1179/joc.2006.18.3.250

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