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Article

The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland.

Journal of psychopharmacology (Oxford, England) - 1 Dec 2004

Kelly Christopher B, McDonnell Anne P, Johnston Timothy G, Mulholland Ciaran, Cooper Stephen J, McMaster Dorothy, Evans Alun, Whitehead Alexander S

Abstract excerpt

Low plasma folate and its derivatives have been linked with depressive disorders in studies dating back over 30 years. A thermolabile variant (677C>T) of the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with low serum folate. The present study aimed to explore whether the thermolabile variant of MTHFR is associated with a vulnerability to depressive episodes. MTHFR C677T genotype...

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Source

Identifiers

PMID: 15582924
DOI: 10.1177/0269881104047285

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland.PMID 15582924Read ↗

The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis.Semantic proximity Read ↗

Genetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke.Semantic proximity Read ↗

No association with the 5,10-methylenetetrahydrofolate reductase gene and major depressive disorder: results of the depression case control (DeCC) study and a meta-analysis.Semantic proximity Read ↗

Polymorphic variants of genes encoding MTHFR, MTR, and MTHFD1 and the risk of depression in postmenopausal women in Poland.Semantic proximity Read ↗

Thermolabile methylenetetrahydrofolate reductase (C677T): frequency in the Irish population.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with major depressive disorder in the Saudi patients attending Erada complex for mental health and Erada services - Jeddah, Saudi Arabia.Semantic proximity Read ↗

The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish populationSemantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review.Semantic proximity Read ↗

Community-living nonagenarians in northern ireland have lower plasma homocysteine but similar methylenetetrahydrofolate reductase thermolabile genotype prevalence compared to 70-89-year-old subjects.Semantic proximity Read ↗

Biological and clinical implications of the MTHFR C677T polymorphism.Semantic proximity Read ↗

Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to depression in Asian population: a systematic meta-analysis.Semantic proximity Read ↗

Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life.Semantic proximity Read ↗

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