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Article

Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction.

QJM : monthly journal of the Association of Physicians - 1 Jun 1996

Adams M, Smith P D, Martin D, Thompson J R, Lodwick D, Samani N J

Abstract excerpt

Hyperhomocyst(e)inemia is associated with an increased risk of coronary artery disease and myocardial infarction. Both genetic and environmental factors influence the plasma level of homocysteine. One of the metabolic pathways for homocysteine involves the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates the conversion of homocysteine to methionine. A thermolabile variant of MTHFR is associated...

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Source

Identifiers

PMID: 8758047
DOI: 10.1093/qjmed/89.6.437

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction.PMID 8758047Read ↗

Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease.Semantic proximity Read ↗

Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction. A case-control study.Semantic proximity Read ↗

Genetic analysis of the thermolabile variant of 5, 10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke.Semantic proximity Read ↗

Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation.Semantic proximity Read ↗

A mutation in the methylenetetrahydrofolate reductase gene is not associated with increased risk for coronary artery disease or myocardial infarction.Semantic proximity Read ↗

Thermolabile methylenetetrahydrofolate reductase polymorphism (C677T) and total homocysteine concentration among African-American and white women.Semantic proximity Read ↗

Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: a potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood.Semantic proximity Read ↗

Distribution in healthy and coronary populations of the methylenetetrahydrofolate reductase (MTHFR) C677T mutation.Semantic proximity Read ↗

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