Article
Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction.
QJM : monthly journal of the Association of Physicians - 1 Jun 1996
Adams M, Smith P D, Martin D, Thompson J R, Lodwick D, Samani N J
Abstract excerpt
Hyperhomocyst(e)inemia is associated with an increased risk of coronary artery disease and myocardial infarction. Both genetic and environmental factors influence the plasma level of homocysteine. One of the metabolic pathways for homocysteine involves the enzyme methylenetetrahydrofolate reducta...
Topics
- Adult
- Aged
- Alleles
- Case-Control Studies
- Female
- Genotype
- Homozygote
- Hot Temperature
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Mutation
- Myocardial Infarction
- Oxidoreductases Acting on CH-NH Group Donors
- Polymerase Chain Reaction
- Prospective Studies
- Risk Factors