Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

Abstract excerpt

cal research (2-5), so the need for disease markers that represent islet-damaging or islet-protective events, such as numbers and phenotype of circulating islet autoreactive T cells, has become more urgent.In terms of distinguishing pathological from protective responses, it has been proposed that proinflammatory (type 1) T cell immunity is responsible for islet damage, while humoral (type 2) immunity may be...

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