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Article

Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes

1 Dec 1996

Abstract excerpt

The infusion of TIL586 along with interleukin-2 into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by TIL586 was previously isolated and shown to encode gp75 or TRP-1. Here we report that TRP-2 was identified as a second tumor antigen recognized by a HLA-A31-restricted CTL clone derived from the TIL586 cell line. The...

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PMID: 8976176
DOI: 10.1084/jem.184.6.2207

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