Article
Translation of a retained intron in tyrosinase-related protein (TRP) 2 mRNA generates a new cytotoxic T lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage.
The Journal of experimental medicine - 21 Sept 1998
Lupetti R, Pisarra P, Verrecchia A, Farina C, Nicolini G, Anichini A, Bordignon C, Sensi M, Parmiani G, Traversari C
Abstract excerpt
We report here the identification of a new shared human melanoma antigen recognized by a human leukocyte antigen (HLA)-A*68011-restricted cytotoxic T lymphocyte clone (CTL 128). The cDNA encoding this antigen is composed of a partially spliced form of the melanocyte differentiation antigen tyrosi...
Topics
- Alleles
- Animals
- Antigen Presentation
- Antigens, Neoplasm
- Base Sequence
- COS Cells
- Cloning, Molecular
- DNA, Complementary
- Epitopes
- Gene Expression Regulation, Neoplastic
- HLA-A3 Antigen
- Histocompatibility Testing
- Humans