Caspase-mediated cleavage of APC results in an amino-terminal fragment with an intact armadillo repeat domain.

doi:10.1096/fasebj.13.2.339

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Article

Caspase-mediated cleavage of APC results in an amino-terminal fragment with an intact armadillo repeat domain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 1999

Webb S J, Nicholson D, Bubb V J, Wyllie A H

Abstract excerpt

During the effector phase of apoptosis, caspase activation appears to be responsible for the distinctive structural changes of apoptosis and perhaps for some of the changes in function of the doomed cells. There is therefore interest in identifying caspase substrates and the details of the cleava...

Topics

Adenomatous Polyposis Coli
Animals
Binding Sites
Blotting, Western
Caspases
Humans
Jurkat Cells
Mice
Mutation
Peptide Fragments
Rats
Substrate Specificity

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