Article
Plasma membrane Ca2+ATPase isoform 4b is cleaved and activated by caspase-3 during the early phase of apoptosis.
The Journal of biological chemistry - 1 Mar 2002
Pászty Katalin, Verma Anil K, Padányi Rita, Filoteo Adelaida G, Penniston John T, Enyedi Agnes
Abstract excerpt
The plasma membrane Ca(2+) pump (PMCA) is an essential element in the complex of mechanisms that maintain low intracellular Ca(2+) concentration in the living cell. This pump is tightly regulated by calmodulin through binding to a high affinity calmodulin-binding domain at the C terminus that also serves as an autoinhibitor of the enzyme. Inspection of the C terminus of hPMCA4b, the most widely distributed form...
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