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Article

Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.

Cell - 26 Jun 1998

Ahmed Y, Hayashi S, Levine A, Wieschaus E

Abstract excerpt

We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apoptotic cell death, which accompanies a defect in neuronal differentiation. Reduction in the Drosophila beta-catenin,...

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Source

Identifiers

PMID: 9657150
DOI: 10.1016/s0092-8674(00)81461-0

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.PMID 9657150Read ↗

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Roles of the C terminus of Armadillo in Wingless signaling in Drosophila.Semantic proximity Read ↗

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