Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.

doi:10.1016/s0092-8674(00)81461-0

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Article

Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development.

Cell - 26 Jun 1998

Ahmed Y, Hayashi S, Levine A, Wieschaus E

Abstract excerpt

We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apopto...

Topics

Adenomatous Polyposis Coli Protein
Animals
Apoptosis
Armadillo Domain Proteins
Cytoskeletal Proteins
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Gene Expression Regulation, Developmental
Genes, APC
Insect Proteins
Mutation
Photoreceptor Cells, Invertebrate
Proto-Oncogene Proteins
Repetitive Sequences, Nucleic Acid
Repressor Proteins
Retina
Retinal Degeneration

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Identifiers

PMID: 9657150
DOI: 10.1016/s0092-8674(00)81461-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9657150-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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