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Article

The APC tumor suppressor promotes transcription-independent apoptosis in vitro.

Molecular cancer research : MCR - 1 Feb 2005

Steigerwald Kira, Behbehani Gregory K, Combs Kelly A, Barton Michelle Craig, Groden Joanna

Abstract excerpt

The APC tumor suppressor is found in nonproliferating epithelial cells of the colonic crypts and is mutated in most colorectal tumors. To understand the function of APC in normal epithelium and how its loss leads to tumor formation, we tested whether APC is a mediator of apoptosis using an in vitro assay that monitors caspase-3-mediated cleavage of lamin B protein or a colorimetric substrate in a cell-free...

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Identifiers

PMID: 15755874
DOI: 10.1158/1541-7786.MCR-03-0189

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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