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Article

Solution structure of the pseudo-5' splice site of a retroviral splicing suppressor.

RNA (New York, N.Y.) - 1 Sept 2004

Cabello-Villegas Javier, Giles Keith E, Soto Ana Maria, Yu Ping, Mougin Annie, Beemon Karen L, Wang Yun-Xing

Abstract excerpt

Control of Rous sarcoma virus RNA splicing depends in part on the interaction of U1 and U11 snRNPs with an intronic RNA element called the negative regulator of splicing (NRS). A 23mer RNA hairpin (NRS23) of the NRS directly binds U1 and U11 snRNPs. Mutations that disrupt base-pairing between the loop of NRS23 and U1 snRNA abolish its negative control of splicing. We have determined the solution structure of...

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Identifiers

PMID: 15317975
DOI: 10.1261/rna.7020804
PMCID: PMC1370626

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Source receipt: pubmed, retrieved 7 Sept 2026.

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