Article
Evidence that atypical protein kinase C-lambda and atypical protein kinase C-zeta participate in Ras-mediated reorganization of the F-actin cytoskeleton.
The Journal of cell biology - 8 Feb 1999
Uberall F, Hellbert K, Kampfer S, Maly K, Villunger A, Spitaler M, Mwanjewe J, Baier-Bitterlich G, Baier G, Grunicke H H
Abstract excerpt
Expression of transforming Ha-Ras L61 in NIH3T3 cells causes profound morphological alterations which include a disassembly of actin stress fibers. The Ras-induced dissolution of actin stress fibers is blocked by the specific PKC inhibitor GF109203X at concentrations which inhibit the activity of...
Topics
- 3T3 Cells
- Actins
- Animals
- Cytoskeleton
- Enzyme Inhibitors
- Indoles
- Isoenzymes
- Maleimides
- Mice
- Microscopy, Fluorescence
- Mutation
- Protein Kinase C
- Signal Transduction
- Transfection
- ras Proteins