Codon 215 Mutations in Human Immunodeficiency Virus–Infected Pregnant Women

doi:10.1086/314615

Article

Codon 215 Mutations in Human Immunodeficiency Virus–Infected Pregnant Women

1 Mar 1999

Abstract excerpt

In 1994, the Pediatric AIDS Clinical Trials Group (PACTG) Protocol 076 demonstrated a two-thirds reduction of perinatal human immunodeficiency virus (HIV) type 1 transmission with zidovudine chemoprophylaxis. However, zidovudine alone does not fully suppress HIV replication, and chemoprophylaxis with zidovudine alone might select for zidovudine-resistant viral variants, decreasing the efficacy of zidovudine...

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