Article
Emergence and clinical relevance of mutations associated with zidovudine resistance in asymptomatic HIV-1 infected patients.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Jun 1995
Calderón E J, Torres Y, Medrano F J, Luque F, Larder B, Rey C, Sánchez-Quijano A, Lissen E, Leal M
Abstract excerpt
The dynamics leading to the emergence of a zidovudine-resistant mutation at codon 215 of the reverse transcriptase coding region was investigated in a cohort of HIV-infected individuals who received early zidovudine therapy. Clinical implications and the role of the resistance mutation at codon 41 were also assessed. Thirty-eight initially asymptomatic HIV-infected patients with a CD4+ cell count above 400...
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