Article
Emergence and clinical relevance of mutations associated with zidovudine resistance in asymptomatic HIV-1 infected patients.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Jun 1995
Calderón E J, Torres Y, Medrano F J, Luque F, Larder B, Rey C, Sánchez-Quijano A, Lissen E, Leal M
Abstract excerpt
The dynamics leading to the emergence of a zidovudine-resistant mutation at codon 215 of the reverse transcriptase coding region was investigated in a cohort of HIV-infected individuals who received early zidovudine therapy. Clinical implications and the role of the resistance mutation at codon 4...
Topics
- Adult
- Antiviral Agents
- Base Sequence
- CD4 Lymphocyte Count
- Codon
- Cohort Studies
- Disease Progression
- Double-Blind Method
- Drug Resistance, Microbial
- Female
- HIV Reverse Transcriptase
- HIV Seropositivity
- HIV-1