Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rate of development of mutation at codon 215 of HIV-1 reverse transcriptase and its predictive factors at the time of initiation of zidovudine therapy.

European journal of clinical investigation - 1 Jun 1996

Leal M, Rey C, Torres Y, Relimpio F, Pino R, Lissen E, Sánchez-Quijano A, Luque F

Abstract excerpt

The objective of the present study was to determine the rate of development of mutation at codon 215 of HIV-1 reverse transcriptase and to identify baseline characteristics associated with this mutation following initiation of zidovudine therapy. To achieve such a purpose, 80 HIV-1-infected patie...

Topics

Adolescent
Adult
Biomarkers
Drug Resistance, Microbial
Female
HIV Infections
HIV Reverse Transcriptase
HIV-1
Humans
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Predictive Value of Tests

Time Factors

Zidovudine

Source

Identifiers

PMID: 8817161
DOI: 10.1046/j.1365-2362.1996.164315.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8817161-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rate of development of mutation at codon 215 of HIV-1 reverse transcriptase and its predictive factors at the time of initiation of zidovudine therapy.PMID 8817161Read ↗

Emergence and clinical relevance of mutations associated with zidovudine resistance in asymptomatic HIV-1 infected patients.Semantic proximity Read ↗

HIV-1 reverse transcriptase codon 215 mutation and clinical outcome in children treated with zidovudine.Semantic proximity Read ↗

Short-term evolution of HIV-1 viraemia and CD4+ cell counts in patients who have a primary mutation to zidovudine.Semantic proximity Read ↗

Occurrence of HIV-1 reverse transcriptase gene mutation at codon 215 in HIV-infected infants.Semantic proximity Read ↗

HIV-1 reverse transcriptase codon 215 mutation in plasma RNA: immunologic and virologic responses to zidovudine. The AIDS Clinical Trials Group Study 175 Virology Team.Semantic proximity Read ↗

Predictive value of codon 215 reverse transcriptase mutation on the efficacy of didanosine in HIV-infected, zidovudine-experienced patients.Semantic proximity Read ↗

Correlation between antiretroviral resistance mutations, biological parameters, and clinical evolution in zidovudine-treated patients infected with human immunodeficiency virus type 1.Semantic proximity Read ↗

Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants.Semantic proximity Read ↗

Codon 215 Mutations in Human Immunodeficiency Virus–Infected Pregnant WomenSemantic proximity Read ↗

HIV-1 syncytium-inducing phenotype, virus burden, codon 215 reverse transcriptase mutation and CD4 cell decline in zidovudine-treated patients.Semantic proximity Read ↗

Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive personsSemantic proximity Read ↗

Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.