Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An endogenous retroviral long terminal repeat at the HLA-DQB1 gene locus confers susceptibility to rheumatoid arthritis.

Human immunology - 1 Jan 1999

Seidl C, Donner H, Petershofen E, Usadel K H, Seifried E, Kaltwasser J P, Badenhoop K

Abstract excerpt

Human endogenous retrovirus (HERV) long terminal repeat (LTR) elements contain regulatory sequences that can influence the expression of adjacent cellular genes, which may contribute to breakdowns of the immune function leading to autoimmune disease. Rheumatoid arthritis (RA) is associated with particular HLA-DR/DQ haplotypes that modulate the pathogenesis of this autoimmune disease. We have therefore studied a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Histocompatibility Testing

Share to HLA-DQ Antigens

Share to HLA-DQ beta-Chains

Source

Identifiers

PMID: 9952028
DOI: 10.1016/s0198-8859(98)00095-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An endogenous retroviral long terminal repeat at the HLA-DQB1 gene locus confers susceptibility to rheumatoid arthritis.PMID 9952028Read ↗

Distribution of HERV-LTR elements in the 5'-flanking region of HLA-DQB1 and association with autoimmunity.Semantic proximity Read ↗

Preliminary evidence that an endogenous retroviral long-terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison's disease.Semantic proximity Read ↗

Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci.Semantic proximity Read ↗

Protection against severe disease is conferred by DERAA-bearing HLA-DRB1 alleles among HLA-DQ3 and HLA-DQ5 positive rheumatoid arthritis patients.Semantic proximity Read ↗

Non-HLA genes modulate the risk of rheumatoid arthritis associated with HLA-DRB1 in a susceptible North American Native population.Semantic proximity Read ↗

Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis.Semantic proximity Read ↗

HLA-DRB1 alleles and shared amino acid sequences in disease susceptibility and severity in patients from eastern France with rheumatoid arthritis.Semantic proximity Read ↗

Endogenous retroviral long terminal repeats within the HLA-DQ locus.Semantic proximity Read ↗

HLA-DR/DQ interaction in patients with erosive rheumatoid arthritis presenting articular and extraarticular disease manifestations.Semantic proximity Read ↗

HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors.Semantic proximity Read ↗

An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition.Semantic proximity Read ↗

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.