Article
An endogenous retroviral long terminal repeat at the HLA-DQB1 gene locus confers susceptibility to rheumatoid arthritis.
Human immunology - 1 Jan 1999
Seidl C, Donner H, Petershofen E, Usadel K H, Seifried E, Kaltwasser J P, Badenhoop K
Abstract excerpt
Human endogenous retrovirus (HERV) long terminal repeat (LTR) elements contain regulatory sequences that can influence the expression of adjacent cellular genes, which may contribute to breakdowns of the immune function leading to autoimmune disease. Rheumatoid arthritis (RA) is associated with p...
Topics
- Arthritis, Rheumatoid
- Case-Control Studies
- Endogenous Retroviruses
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Histocompatibility Testing
- Humans
- Middle Aged
- Terminal Repeat Sequences