Article
An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition.
Immunogenetics - 1 Jan 2000
Zanelli E, Huizinga T W, Guerne P A, Vischer T L, Tiercy J M, Verduyn W, Schreuder G M, Breedveld F C, de Vries R R
Abstract excerpt
In the present study, we tested our hypothesis on the role of a DQ-DR haplotype in rheumatoid arthritis (RA) predisposition. Using two groups of patients and controls, one from The Netherlands and one from Switzerland, we found that DQA1*0301-homozygous and DQA1*0301//DQA1*0101/04-heterozygous in...
Topics
- Arthritis, Rheumatoid
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Heterozygote
- Homozygote
- Humans