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Article

Preliminary evidence that an endogenous retroviral long-terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison's disease.

Clinical endocrinology - 1 Jun 2002

Pani Michael A, Seidl Christian, Bieda Katrin, Seissler Jochen, Krause Maren, Seifried Erhard, Usadel Klaus-H, Badenhoop Klaus

Abstract excerpt

OBJECTIVE: Addison's disease is associated with particular haplotypes of the human leucocyte antigen (HLA) region [DQA1*0501-DQB1*0201 (DQ2) and DQA1*0301-DQB1*0302 (DQ8)]. This locus harbours several human endogenous retroviral (HERV) long-terminal repeats (LTR). LTRs within the HLA region have been shown to confer additional susceptibility to type 1 diabetes and rheumatoid arthritis. DESIGN: We investigated the...

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Source

Identifiers

PMID: 12072047
DOI: 10.1046/j.1365-2265.2002.t01-1-01548.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Preliminary evidence that an endogenous retroviral long-terminal repeat (LTR13) at the HLA-DQB1 gene locus confers susceptibility to Addison's disease.PMID 12072047Read ↗

Retrovirus-like long-terminal repeat DQ-LTR13 and genetic susceptibility to type 1 diabetes and autoimmune Addison's disease.Semantic proximity Read ↗

A retroviral long terminal repeat adjacent to the HLA DQB1 gene (DQ-LTR13) modifies Type I diabetes susceptibility on high risk DQ haplotypes.Semantic proximity Read ↗

An endogenous retroviral long terminal repeat at the HLA-DQB1 gene locus confers susceptibility to rheumatoid arthritis.Semantic proximity Read ↗

Distribution of HERV-LTR elements in the 5'-flanking region of HLA-DQB1 and association with autoimmunity.Semantic proximity Read ↗

Analysis of extended human leukocyte antigen haplotype association with Addison's disease in three populationsSemantic proximity Read ↗

The presence or absence of a retroviral long terminal repeat influences the genetic risk for type 1 diabetes conferred by human leukocyte antigen DQ haplotypes. Belgian Diabetes Registry.Semantic proximity Read ↗

Genetic dissection of<i>HLA-DRB1*15:01</i>and XL9 region variants in Japanese patients with systemic lupus erythematosus: Primary role for<i>HLA-DRB1*15:01</i>Semantic proximity Read ↗

Association of HLA-DR3 and HLA-DR15 Polymorphisms with Risk of Systemic Lupus ErythematosusSemantic proximity Read ↗

Genetic dissection of HLA-DRB1*15:01 and XL9 region variants in Japanese patients with systemic lupus erythematosus: primary role for HLA-DRB1*15:01.Semantic proximity Read ↗

Role of the Human Endogenous Retrovirus HERV-K18 in Autoimmune Disease Susceptibility: Study in the Spanish Population and Meta-AnalysisSemantic proximity Read ↗

Multiple loci in the HLA complex are associated with Addison's disease.Semantic proximity Read ↗

"Extended" A1, B8, DR3 haplotype shows remarkable linkage disequilibrium but is similar to nonextended haplotypes in terms of diabetes risk.Semantic proximity Read ↗

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