Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.

The Journal of clinical investigation - 1 Jun 1992

Weyand C M, Xie C, Goronzy J J

Abstract excerpt

Seropositive rheumatoid arthritis is genetically linked to a group of HLA-DRB1 alleles sharing a sequence motif within the third hypervariable region. Controversy exists over the role of the distinct allelic variants in affecting not only the risk to develop disease, but also in modifying the expression of the disease. We have stratified 81 patients according to their patterns of disease manifestations and...

Topics

Alleles
Arthritis, Rheumatoid
Base Sequence
DNA
Female
Genotype
HLA-DR Antigens
HLA-DRB1 Chains
Histocompatibility Antigens Class II
Homozygote
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Phenotype

Rheumatoid Nodule

Source

Open in PubMed Open full text

Identifiers

PMID: 1602009
DOI: 10.1172/JCI115814
PMCID: PMC295917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1602009-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis.PMID 1602009Read ↗

The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis.Semantic proximity Read ↗

Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis.Semantic proximity Read ↗

Association of MHC and rheumatoid arthritis. HLA polymorphisms in phenotypic variants of rheumatoid arthritis.Semantic proximity Read ↗

HLA-DRB1 alleles and shared amino acid sequences in disease susceptibility and severity in patients from eastern France with rheumatoid arthritis.Semantic proximity Read ↗

Only weak association between disease severity and HLA-DRB 1 genes in a Swiss population of rheumatoid arthritis patients.Semantic proximity Read ↗

Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes.Semantic proximity Read ↗

HLA-DR/DQ interaction in patients with erosive rheumatoid arthritis presenting articular and extraarticular disease manifestations.Semantic proximity Read ↗

Disease-associated human histocompatibility leukocyte antigen determinants in patients with seropositive rheumatoid arthritis. Functional role in antigen-specific and allogeneic T cell recognition.Semantic proximity Read ↗

A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis.Semantic proximity Read ↗

HLA-DRB1 alleles as severity markers in RA.Semantic proximity Read ↗

Relative predispositional effects and mode of inheritance of HLA-DRB1 alleles among community-based Caucasian females with rheumatoid arthritis.Semantic proximity Read ↗

The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.